Webinar Details:
Time: Tuesday, December 3, 11:00 AM Boston/ 5:00 PM Paris/ 9:30 PM Delhi
Link: https://nyu.zoom.us/j/91419770855
Professor Tatyana Polenova of the University of Delaware
Title: Integrative Structural Biology of Protein Assemblies: Challenges and Opportunities for Magnetic Resonance
Abstract: I will present recent developments in MAS NMR techniques for atomic-resolution structural analysis of large biological assemblies. Drawing on studies of diverse systems from our lab, including the kinesin motor domain with polymerized microtubules, cofilin bound to filamentous actin, and HIV-1 protein assemblies interacting with small-molecule maturation inhibitors, I will illustrate how with MAS NMR, structural and dynamic details, as well as drug interactions were uncovered, that are inaccessible using other approaches. Additionally, I will discuss the benefits of combining MAS NMR with medium-resolution cryo-EM and MD simulations to enhance structural understanding, and address the current challenges and future directions for magnetic resonance in integrative structural biology.
Speaker’s Biography:
1997: Ph.D., Columbia University, USA
1997-1999: Postdoc, Columbia University, USA
1999-2003: Assistant Professor, Hunter College, City University of New York, USA
2003-2006: Assistant Professor, University of Delaware, USA
2006-2011: Associate Professor, University of Delaware, USA
2011-present: Professor, University of Delaware, USA